| Autor: |
Bonnet, Hugues, Morel, Maéva, Devaux, Alexandre, Boissieras, Joseph, Granzhan, Anton, Elias, Benjamin, Lavergne, Thomas, Dejeu, Jérôme, Defrancq, Eric |
| Předmět: |
|
| Zdroj: |
Chemical Communications; 4/28/2022, Vol. 58 Issue 33, p5116-5119, 4p |
| Abstrakt: |
Biolayer interferometry (BLI) and circular dichroism (CD) spectroscopy were used to investigate the interaction between previously reported i-motif DNA (i-DNA) ligands and folded or unfolded i-DNA in acidic (pH 5.5) and near-neutral (pH 6.5) conditions. We observed that although several ligands, in particular macrocyclic bis-acridine (BisA) and pyridostatin (PDS), showed good affinities for the telomeric i-motif forming sequence, none of the ligands displayed selective interactions with the i-DNA structure nor was able to promote its formation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
