| Autor: |
Nakano, Dan, Kawaguchi, Takumi, Tsutsumi, Tsubasa, Hayakawa, Masako, Yoshio, Sachiyo, Koga, Hironori, Torimura, Takuji |
| Předmět: |
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| Zdroj: |
JGH Open; Apr2022, Vol. 6 Issue 4, p270-273, 4p |
| Abstrakt: |
AMPK is known to inhibit the various chemokine expressions.9 Furthermore, mitochondrial dysfunction is reported to regulate the M-CSF level.10 Accordingly, SGLT2i may affect mitochondria in HCC cells and modulate the expression of several chemokines/cytokines. Keywords: chemokine; cytokine; hepatoma; sodium-glucose cotransporter 2; tumor microenvironment EN chemokine cytokine hepatoma sodium-glucose cotransporter 2 tumor microenvironment 270 273 4 04/25/22 20220401 NES 220401 (a) Summary for SGLT2i-induced alterations in 48 chemokines/cytokines in Hep3B and Huh7 cells. Of the measured 48 chemokines/cytokines, there was no significant alteration in the medium level of 40 and 39 chemokines/cytokines between the SGLT2i and control groups in Hep3B and Huh7 cells (Tables S1 and S2, Supporting information). HCC releases various chemokines/cytokines to modulate the tumor microenvironment and regulates the proliferation and invasion of HCC cells.4,5 The aim of this study was to investigate the direct effects of SGLT2i on tumor-releasing chemokines/cytokines in human HCC cell lines. [Extracted from the article] |
| Databáze: |
Complementary Index |
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