| Autor: |
Damasceno de Lima, Robson, Pedersen, Matheus, Costa do Bomfim, Fernando Russo, Chiarotto, Gabriela Bortolança, Canciglieri, Paulo Henrique, Pauli, José Rodrigo, Felonato, Maíra |
| Předmět: |
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| Zdroj: |
Cell Biochemistry & Function; Apr2022, Vol. 40 Issue 3, p321-332, 12p |
| Abstrakt: |
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and involvement of the synovial membrane, causing joint damage and deformities. No effective drug treatment is available, and physical exercise has been utilized to alleviate the inflammatory processes. This study aimed to investigate the effects of different exercise training protocols on Zymosan‐induced RA inflammatory markers in the right knee of Wistar rats. The rodents were subjected to aerobic, resisted, and combined physical training protocols with variations in the total training volume (50% or 100% of resistance and aerobic training volume) for 8 weeks. All physical training protocols reduced cachexia and systemic inflammatory processes. The histological results showed an increase in the inflammatory influx to the synovial tissue of the right knee in all physical training protocols. The rats that underwent combined physical training with reduced volume had a lower inflammatory influx compared to the other experimental groups. A reduction in the mRNA expression of inflammatory genes and an increase in anti‐inflammatory gene expression were also observed. The physical training protocol associated with volume reduction attenuated systemic and synovial inflammation of the right knee, reducing the impact of Zymosan‐induced RA in rats. Key points: All physical training protocols reduced cachexia and systemic inflammatory processes.The moderate‐volume combined physical training protocol showed reduced expression of inflammatory genes.The combined moderate volume physical training protocol showed reduced levels of messenger RNA from the TH1 and TNF‐α genes and showed the immunomodulatory effect of interleukin‐10. Significance statement: Rheumatoid arthritis (RA) is an autoimmune disease characterized by an intense inflammatory process, especially in the synovial membrane. Physical exercise is used as nondrug treatment to alleviate inflammation and to increase the functional capacity of affected patients. We investigated the effects of different physical training protocols (aerobic, resistance, and combined) with varying total training volumes (TVs) on Zymosan‐induced rheumatoid arthritis in the right knee of Wistar rats. All physical training protocols reduced cachexia and systemic inflammation, but only combined physical training (resistance + aerobic) with a 50% reduced total volume reduced the synovial tissue inflammation of the right knee. These findings provide new insights into the processes involved in TV and systemic and synovial tissue inflammation in RA. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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