| Autor: |
Wurth, Rachel, Hajdenberg, Michelle, Barrera, Francisco J., Shekhar, Skand, Copacino, Caroline E., Moreno-Peña, Pablo J., Gharib, Omar A. M., Porter, Forbes, Hiremath, Swapnil, Hall, Janet E., Schiffrin, Ernesto L., Eisenhofer, Graeme, Bornstein, Stefan R., Brito, Juan P., González-González, José Gerardo, Stratakis, Constantine A., Rodríguez-Gutiérrez, René, Hannah-Shmouni, Fady |
| Předmět: |
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| Zdroj: |
Postgraduate Medical Journal; May2022, Vol. 98 Issue 1159, p372-379, 8p |
| Abstrakt: |
Aim: The aim of this study was to systematically appraise the quality of a sample of COVID-19-related systematic reviews (SRs) and discuss internal validity threats affecting the COVID-19 body of evidence.Design: We conducted a scoping review of the literature. SRs with or without meta-analysis (MA) that evaluated clinical data, outcomes or treatments for patients with COVID-19 were included.Main Outcome Measures: We extracted quality characteristics guided by A Measurement Tool to Assess Systematic Reviews-2 to calculate a qualitative score. Complementary evaluation of the most prominent published limitations affecting the COVID-19 body of evidence was performed.Results: A total of 63 SRs were included. The majority were judged as a critically low methodological quality. Most of the studies were not guided by a pre-established protocol (39, 62%). More than half (39, 62%) failed to address risk of bias when interpreting their results. A comprehensive literature search strategy was reported in most SRs (54, 86%). Appropriate use of statistical methods was evident in nearly all SRs with MAs (39, 95%). Only 16 (33%) studies recognised heterogeneity in the definition of severe COVID-19 as a limitation of the study, and 15 (24%) recognised repeated patient populations as a limitation.Conclusion: The methodological and reporting quality of current COVID-19 SR is far from optimal. In addition, most of the current SRs fail to address relevant threats to their internal validity, including repeated patients and heterogeneity in the definition of severe COVID-19. Adherence to proper study design and peer-review practices must remain to mitigate current limitations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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