| Autor: |
Coez, A., Fillon, L., Saitovitch, A., Rutten, C., Marlin, S., Boisgontier, J., Vincon-Leite A., Lemaitre, H., Grévent, D., Roux, C. -J, Dangouloff-Ros V., Levy, R., Bizaguet, E., Rouillon, I., Noël Garabédian, E., Denoyelle, F., Zilbovicius, M., Loundon, N., Boddaert, N. |
| Předmět: |
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| Zdroj: |
Journal of Hearing Science; 2022, Vol. 12 Issue 1, p47-47, 1/2p |
| Abstrakt: |
Objectives: We had investigated differences in cerebral blood flow (CBF) at rest prior to implantation in children with congenital deafness compared to normally hearing children. Material and methods: Retrospective study included 79 children, candidates for cochlear implantation between 2012 and 2018. All patients underwent a brain and inner ear MRI, a routine MRI protocol including ASL-MRI. The median age at time of MRI scan was 3.2 years (range 0.5 to 15.8 years). A control group was composed of 86 normally hearing children with a median age at time of MRI scan of 2.9 years (range 0.5 to 13.0 years). Participants were divided into 3 subgroups based on their age at time of MRI. A subgroup under 2 years of age was composed of 28 patients and 33 controls. A subgroup aged between 2 and 5 years of age was composed of 26 deaf patients and 20 controls. A subgroup older than 5 years of age was composed of 25 deaf patients and 33 controls. For children over 5 years old, prior to cochlear implantation (CI) and following hearing aid rehabilitation the mean intelligibility score was of 64.5±32%, and was 92±11.5% twelve months after CI. There was no correlation between age and intelligibility scores either before or after cochlear implantation. Results: In deaf children older than 5 years old, results showed a significant bilateral hypoperfusion in temporal regions, and a significant hyperperfusion of occipital regions. Furthermore, whole brain voxel-by-voxel correlation analysis between preoperative rest-CBF and oral intelligibility scores at 12 months post-implantation, showed significant negative correlation localized in the occipital regions. Finally, when comparing mean relative perfusion across ages in patients and controls, we observed that temporal perfusion increased with age in normally hearing children, although it remained stable in deaf children. Conlusions: Children who performed worse in the speech perception test one year after implantation were those presenting higher preoperative CBF values in these occipital regions. We showed a critical period around 4 years old, where in the context of auditory deprivation, there is a lack of synaptic activity in auditory regions. These results support the benefits of early cochlear implantation to maximize the effectiveness of auditory rehabilitation and to avoid cross-modal reorganization. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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