Comparative molecular genomic analyses of a spontaneous rhesus macaque model of mismatch repair-deficient colorectal cancer.

Autor:	Ozirmak Lermi, Nejla, Gray, Stanton B., Bowen, Charles M., Reyes-Uribe, Laura, Dray, Beth K., Deng, Nan, Harris, R. Alan, Raveendran, Muthuswamy, Benavides, Fernando, Hodo, Carolyn L., Taggart, Melissa W., Colbert Maresso, Karen, Sinha, Krishna M., Rogers, Jeffrey, Vilar, Eduardo
Předmět:	MACAQUES RHESUS monkeys COLORECTAL cancer GENOMICS HEREDITARY nonpolyposis colorectal cancer GENE expression profiling
Zdroj:	PLoS Genetics; 4/21/2022, Vol. 18 Issue 4, p1-23, 23p
Abstrakt:	Colorectal cancer (CRC) remains the third most common cancer in the US with 15% of cases displaying Microsatellite Instability (MSI) secondary to Lynch Syndrome (LS) or somatic hypermethylation of the MLH1 promoter. A cohort of rhesus macaques from our institution developed spontaneous mismatch repair deficient (MMRd) CRC with a notable fraction harboring a pathogenic germline mutation in MLH1 (c.1029C
Databáze:	Complementary Index
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