| Autor: |
Chen, Lizhen, Xie, Wenyang, Luo, Yao, Ding, Xiaolan, Fu, Bing, Gopinath, Subash C.B., Xiong, Yuanhuan |
| Předmět: |
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| Zdroj: |
Biotechnology & Applied Biochemistry; Apr2022, Vol. 69 Issue 2, p840-847, 8p |
| Abstrakt: |
A highly sensitive silica‐alumina (Si‐Al)‐modified capacitive non‐Faradaic glucose biosensor was introduced to monitor gestational diabetes. Glucose oxidase (GOx) was attached to the Si‐Al electrode surface as the probe through amine‐modification followed by glutaraldehyde premixed GOx as aldehyde‐amine chemistry. This Si‐Al (∼50 nm) modified electrode surface has increased the current flow upon binding of GOx with glucose. Capacitance values were increased by increasing the glucose concentrations. A mean capacitance value was plotted and the detection limit was found as 0.03 mg/mL with the regression coefficient value, R² = 0.9782 [y = 0.8391x + 1.338] on the linear range between 0.03 and 1 mg/mL. Further, a biofouling experiment with fructose and galactose did not increase the capacitance, indicating the specific glucose detection. This Si‐Al–modified capacitance sensor detects a lower level of glucose presence and helps in monitoring gestational diabetes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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