| Autor: |
Martínez, Osmel Fleitas, Duque, Harry Morales, Franco, Octávio Luiz |
| Předmět: |
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| Zdroj: |
Frontiers in Microbiology; 4/18/2022, Vol. 13, p1-18, 18p |
| Abstrakt: |
Keywords: peptidomimetics; anti-virulence; biofilms; quorum sensing; secretion systems; resistance EN peptidomimetics anti-virulence biofilms quorum sensing secretion systems resistance 1 18 18 04/21/22 20220418 NES 220418 Introduction The WHO has recognized antimicrobial resistance as a serious global public health threat ([154]). Due to their multiprotein composition, protein-protein interactions are a particularly important process in secretion system assembly and function; consequently, protein-protein interactions could be a target to be exploited for the development of novel peptidomimetics with anti-virulence activity. Nal-P-113 appears to exert anti-biofilm activity against I Porphyromonas gingivalis i W83 biofilms through different mechanisms, dependent on peptide concentrations ([147]). Recently, functionalized proline-rich peptides with the capacity to bind selectively to c-di-GMP showed anti-biofilm activity against I P. aeruginosa i biofilms ([33]). The peptides were assayed to evaluate their biofilm inhibitory capacity, and Ac-Gup-Gup-Nap-Arg-NH2 and Ac-Nap-Gup-Gup-Nap-Arg-NH2 were the most active peptides (Table 2; [33]). [Extracted from the article] |
| Databáze: |
Complementary Index |
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