| Autor: |
Wang, Jinjing, Zhang, Yi, Sun, Jianfei, Jiao, Zhen |
| Předmět: |
|
| Zdroj: |
Journal of Applied Polymer Science; Jun2022, Vol. 139 Issue 23, p1-13, 13p |
| Abstrakt: |
Multi‐modal porous scaffolds can promote bone regeneration. In the present study, they were successfully fabricated from poly (lactic‐co‐glycolic acid) (PLGA)/superparamagnetic iron oxide nanoparticles (SPIONs) by supercritical CO2 foaming, where SPIONs was employed as heterogeneous nucleation agent. The effects of SPION size on pore nucleation in PLGA/SPIONs nanocomposites were investigated. It was found that the addition of smaller SPIONs size caused the reduction of pore size. Multi‐modal porous scaffolds could be available by controlling the SPIONs content, soaking temperature, pressure, and depressurization rate. The porosity of the PLGA/SPIONs scaffolds ranged from (58.68 ± 0.62)% to (94.97 ± 0.14)% could be obtained via adjusting the supercritical CO2 foaming conditions. Moreover, it was found that the compressive modulus and porosity of the scaffolds were strongly associated with the porous structure. This study provided a new green preparation method for magnetic scaffolds to realize the controllable adjustment of the multi‐mode porous scaffolds. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Plný text