Hemisynthesis of coumarin derivatives from Ammodaucus leucotrichus oil extract: organobase-catalyzed reaction, analytical study by diffusion-ordered spectroscopy NMR and differential scanning calorimetry.

Autor: Hassaine, Ridha, El Haci, Imad Abdelhamid, Dergal, Fayçal, Boukennna, Leϊla, Khoukh, Abdelouahed, Negadi, Sofiane, Taibi, Nadia, Bachari, Khaldoun, Choukchou-Braham, Noureddine
Předmět:
Zdroj: Natural Product Research; May2022, Vol. 36 Issue 9, p2284-2291, 8p
Abstrakt: This paper presents an in-depth chemical and analytical study of a natural substance extracted from Ammodaucus leucotrichus Coss. & Dur and its derivatives after hemisynthesis. The analysis was performed using Diffusion-Ordered Spectroscopy (NMR DOSY) and Differential Scanning Calorimetry (DSC) as general methods. The results show an interesting chemical reactivity towards coumarin-derived bisnucleophiles (4-hydroxycoumarin and triacetic acid lactone), and products obtained by hemisynthesis of pyrano[4,3-b]pyrane derivatives following Knoevenagel condensation and Michael's addition on this natural substance with the use of 4-pyrolidinopyridine organobase as catalyst. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index