| Autor: |
Goloktionov, Nikolaj Aleksandrovich, Kashnikov, Vladimir Nikolaevich, Tkalich, Olga Vladimirovna, Ponomarenko, Aleksej Alekseevich, Khryukin, Roman Yurevich, Kostarev, Ivan Vasilevich, Krstic, Predrag, Slozhenikin, Sergej Valerevich, Zagryadskiy, Evgenij Alekseevich, Medvedev, Vladimir Yurevich, Fomenko, Oksana Yurevna, Nekhrikova, Svetlana Viktorovna, Arslanbekova, Karina Ibakovna, Misikov, Viktor Kazbekovich, Akulov, Mikhail Albertovich, Orlova, Aleksandra Sergeevna, Zharkov, Evgenij Evgenevich |
| Předmět: |
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| Zdroj: |
Serbian Journal of Experimental & Clinical Research; Mar2022, Vol. 23 Issue 1, p13-28, 16p |
| Abstrakt: |
Objective: To compare the results of chronic anal fissure treatment with 10 IU and 40 IU botulinum toxin type A. Patients and methods: 56 patients were enrolled in case-control study divided into 2 groups consistent by the main clinical criteria. 28 patients in the study group had fissure excision in combination with 10 IU botulinum toxin type A (Xeomin) injection into internal anal sphincter, while 28 patients in control group received 40 IU product injections. Results: No statistically significant results in the pain assessment during the day and after bowel movement were obtained (p=0.41 and p=0.93, respectively). The groups were comparable by the frequency of complications such as transient anal incontinence, perianal skin hematoma, acute urinary retention (p>0.05). Complications such as thrombosis of external hemorrhoids and chronic non-healing wounds were most common in the study group (p=0.43 and p=0.0005, respectively). The product dose increase to 40 IU has a more significant effect on the functional treatment results (p=0.0053 and p=0.0002, respectively) and increases the odds for postoperative wound epithelialization 15-fold (p=0.01). Conclusion: 40 IU Botulinum toxin type A shows improvement in the treatment of chronic anal fissure without any increased risk of postoperative complications. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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