| Autor: |
Avagyan, Hranush, Mirzoyan, Anaida, Mirzoyan, Ferdinand, Izmailyan, Roza, Hakobyan, Sona, Voskanyan, Henry, Semerjyan, Zara, Avetisyan, Aida, Arzumanyan, Hranush, Karalova, Elena, Abroyan, Liana, Hakobyan, Lina, Bayramyan, Nane, Gevorgyan, Nazeli, Karalyan, Alexander, Karalyan, Zaven |
| Předmět: |
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| Zdroj: |
Antiviral Chemistry & Chemotherapy; 4/7/2022, p1-10, 10p |
| Abstrakt: |
The water-based combination of two inorganic chemical compounds such as sodium tungstate dihydrate-Na2WO4 × 2H2O and Aluminum sulfate octadecahydrate-Al2 (SO4) 3 × 18H2O that we have conditionally named 'Vomifal' has a broad antiviral activity in various DNA and RNA viruses, including Human Herpes Virus (HHV), African Swine Fever Virus (ASFV), Vaccinia Virus (VV), Hepatitis C Virus (HCV), Foot and Mouth Disease Virus (FMDV), Influenza A virus (A/Aichi/2/68 (H3N2)). In vitro and In vivo assays in several tissue cultures as well as in laboratory animals, conformed 'Vomifal' has a very low toxicity and the antiviral properties partially are due to its ability to induce gamma-IFN. Based on the results obtained, we can assume the presence of at least two mechanisms of the antiviral action of the studied drug. First or early stage - an unknown mechanism, possibly related to the effect on cellular receptors. Second or late stage – main antiviral properties probably associated with an interferonogenic effect. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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