| Autor: |
Zhou, Bei, He, Yu-Juan, Tao, Yun-Feng, Liu, Lan-Xiang, Hu, Min, Chang, Zu-Hui, Lei, Hong, Lin, Jun, Lin, Tong, Du, Guan-Ben |
| Předmět: |
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| Zdroj: |
Green Chemistry; 4/7/2022, Vol. 24 Issue 7, p2859-2870, 12p |
| Abstrakt: |
A novel, environmentally friendly electrocatalytic process has been developed to prepare α,α-gem-dihalide (F, Cl, and Br) ketones from α-mono-halide ketones in an aqueous solution containing alkali halide salts. The gem-dihalides could have the same or different halogens on the same carbon, depending on the reactant and inorganic halide salt used. An electron-withdrawing group, such as carbonyl, located at the α-site of mono-halogenated carbon, was essential to the reaction. The electrosyntheses were performed under ambient conditions without inert gas protection and displayed yields of about 80%. This method avoided the classical haloform elimination reaction. However, when the aqueous solution contained NaOH, two α-mono-halide ketone molecules had a special dimer condensation. The reaction mechanisms were explored by conducting GC-MS, EPR, and CV with DFT calculations. These revealed that in situ generation of a halogen radical initiated electrocatalytic halogenation, while the dimer condensation involved a hydroxyl radical-mediated C1 fragment elimination. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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