| Autor: |
Pinhasov, A., Ilyin, E., Crooke, J., Amato, F. A., Vaidya, A. H., Rosenthal, D., Brenneman, D. E., Malatynska, E. |
| Předmět: |
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| Zdroj: |
Genes, Brain & Behavior; Feb2005, Vol. 4 Issue 1, p60-64, 5p, 1 Diagram, 3 Graphs |
| Abstrakt: |
Synucleins are small proteins regulating the filamentous network that in turn influences the release of dopamine and glutamate neurotransmitters involved in mood and motivation processes. We have studied the pattern of synuclein expression in animal models for mania and depression. Dominant behavior, as defined in a food competition test with dyads of rats, can serve as a model of mania and submissive behavior as a model of depression. The expression ofα-,β- andγ-synuclein was analyzed in four regions of cortex from dominant, neutral and submissive rats using TaqMan reverse transcription-polymerase chain reaction technology. The expression levels ofγ-synuclein were elevated consistently in all regions of cerebral cortex of dominant rats (P < 0.05; 23.5 ± 1.1, normalized units) in contrast to the submissive rat group (10.3 ± 1.2). Neutral rats had intermediate cerebral cortex levels ofγ-synuclein expression (15.7 ± 1.4) that were significantly lower than that in dominant rats (P < 0.05). No changes inα- orβ-synuclein expression were observed among the groups. These studies indicate thatγ-synuclein levels in the cerebral cortex were differentially associated with dominant and submissive behavior. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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