Safety of jidabokuippo administration based on adverse event rate.

Autor: Kitamura, Toshiharu, Nakae, Hajime, Irie, Yasuhito, Satoh, Kasumi, Hirasawa, Nobuhisa, Kameyama, Koumei, Suzuki, Yuya, Maeno, Kyohei, Yoshida, Kenji, Okuyama, Manabu
Předmět:
Zdroj: Traditional & Kampo Medicine; Apr2022, Vol. 9 Issue 1, p18-24, 7p
Abstrakt: Aim: The incidence of adverse events associated with Kampo prescriptions is still unclear. We retrospectively studied the adverse events in 1104 patients prescribed jidabokuippo (JDI) to examine the safety of JDI based on adverse event rate. Methods: Adverse events to JDI treatment were observed in 14 patients (adverse event group) while 1090 had none (non‐adverse event group). We compared age, sex, comorbidity, dose, dosing period, concomitant use of Kampo prescription, and concomitant use of analgesics between these two groups. Results: The adverse event rate was 1.3%. The most common adverse event was diarrhea caused by rhubarb rhizome (0.6%). The adverse event rate of Glycyrrhiza‐induced pseudoaldosteronism was 0.3%. All symptoms improved on JDI withdrawal or taking JDI after meals. Median duration of JDI was significantly shorter in the adverse event group than in the non‐adverse event group (P = 0.0141). Conclusion: The adverse event rate associated with JDI use was low and onset was relatively rapid. We can further reduce this adverse event rate by paying attention to the pharmacological action of rhubarb rhizome and Glycyrrhiza root. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje