Spurious results for total and free prostate-specific antigen (PSA); sometimes really "a riddle wrapped in a mystery inside an enigma".

Autor: Dorizzi, Romolo Marco, Maltoni, Paolo, Sgarzani, Claudio, Torello, Monica, Montanari, Francesco
Předmět:
Zdroj: Clinical Chemistry & Laboratory Medicine; Apr2022, Vol. 60 Issue 5, pe91-e94, 4p
Abstrakt: The capture antibody of Roche assay was included in group 6b antibodies that cross-reacts with human kallikrein (hK2) and recognizes the PSA amino-terminal 3-11 region while the tracer antibody was included in group 4b antibodies that react equally with free and complexed PSA and recognizes an unclear region. Keywords: free prostate-specific antigen; immuno-assays; interferences; total prostate-specific antigen EN free prostate-specific antigen immuno-assays interferences total prostate-specific antigen e91 e94 4 04/05/22 20220401 NES 220401 To the Editor, A recent editorial mentioned the confusion of clinicians and patients who have to deal with "disparate results obtained from different manufacturers" underpinned by the inter-method bias of total (tPSA) and free prostate-specific antigen (fPSA) assays still in need to be harmonized [[1]]. [Extracted from the article]
Databáze: Complementary Index