| Autor: |
Tumanova, O. Yu., Kuvshinov, V. N., Il'ichev, A. A., Nekrasov, B. G., Ivanisenko, V. A., Kozlov, A. P., Sandakhchiev, L. S. |
| Předmět: |
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| Zdroj: |
Molecular Biology; Jul2002, Vol. 36 Issue 4, p517-521, 5p |
| Abstrakt: |
A phage peptide library was used to select peptides interacting with virus-neutralizing monoclonal antibodies (mAb) 2G12 which recognize a discontinuous surface epitope of HIV-1 gp120. With the published X-ray data, gp120 regions involved in the antigenic determinant were predicted. Binding with mAb 2G12 was ascribed to Thr297, Phe383, Tyr384, Arg419, Ile240, Thr415, Leu416, Pro417, Lys421, and Trp112. Though distant in the gp120 sequence, these residues are close in space and form the 2G12 epitope on the gp120 surface. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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