The release of β glucuronidase from the white cells of patients with drug rashes when incubated in autologous plasma, with and without the addition of the causal drug.

Autor: Watson, Brian, Rhodes, E. L., Rosling, A. E.
Předmět:
Zdroj: British Journal of Dermatology; Aug1978, Vol. 99 Issue 2, p183-190, 8p
Abstrakt: In seven out of 16 patients with drug rashes, the leucocytes selectively released β glucuronidase when incubated in autologous plasma, indicating the possible presence of immune complexes. When the white cells were incubated with the suspected drug in vitro, they tended to react in three different ways. In four out of 16 cases additional β glucuronidase was released, perhaps due to the formation of immune complexes, in two out of the 16, β glucuronidase release was suppressed, perhaps due to antigen excess, and in two cases LDH release was decreased white β glucuronidase remained unaltered. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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