| Autor: |
Albani, C. M., Borgo, J., Fabbri, J., Pensel, P., Fasciani, L., Elso, O., Papademetrio, D., Grasso, D., Paladini, A., Beer, M. F., Farias, N. E., Elissondo, N., Gambino, G., Zoppi, J., Sülsen, V., Elissondo, M. C. |
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| Zdroj: |
Parasitology; Apr2022, Vol. 149 Issue 4, p519-528, 10p |
| Abstrakt: |
Keywords: Anti-parasitic treatment; cystic echinococcosis; phytotherapy; plant extract EN Anti-parasitic treatment cystic echinococcosis phytotherapy plant extract 519 528 10 03/29/22 20220401 NES 220401 Introduction Cystic echinococcosis (CE) is a worldwide zoonotic disease caused by the larval stage of the parasite I Echinococcus granulosus sensu lato i ( I s.l. i ) which provokes long-term infections in humans and animals, being a serious public health problem (Pavletic I et al i ., 2017). Based on the World Health Organization Informal Working Group on Echinococcosis (WHO-IWGE) classification of cyst stages by imaging-based techniques, four treatment options have been suggested: percutaneous-aspiration-injection and re-aspiration (PAIR), surgery, anti-parasitic therapy with benzimidazoles (BZM) and a watch-and-wait approach for inactive cysts (Siles-Lucas I et al i ., 2018). For I in vitro i studies involving Huh7 cells, the I S. multiaristata i extract (10 mg) was sequentially resuspended in 20 I i L of DMSO, 40 I i L of ethanol 96% and finally, 40 I i L of deionized water, giving a solution of 100 mg mL SP -1 sp . We found that the I S. multiaristata i extract caused both an I in vitro i effect on protoscoleces and cysts and also an I in vivo i therapeutic effect. [Extracted from the article] |
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Complementary Index |
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