| Autor: |
Wong, W. M., Xiao, S. D., Hu, P. J., Wang, W. H., Gu, Q., Huang, J. Q., Xia, H. H.‐X., Wu, S. M., Li, C. J., Chen, M. H., Cui, Y., Lai, K. C., Hu, W. H. C., Chan, C. K., Lam, S. K., Wong, B. C.‐Y. |
| Předmět: |
|
| Zdroj: |
Alimentary Pharmacology & Therapeutics; Jan2005, Vol. 21 Issue 1, p73-81, 9p |
| Abstrakt: |
: Recent studies suggest that theHelicobacter pylorieradication rate in patients with non-ulcer dyspepsia is lower when compared to patients with peptic ulcer diseases.: The aim of this study was to study the efficacy of triple therapy forH. pyloriinfection in patients with duodenal ulcer vs. patients with non-ulcer dyspepsia.: A total of 582 Chinese patients with provenH. pyloriinfection were recruited to receive: omeprazole 20 mg, amoxicillin 1000 mg and clarithromycin 500 mg all given twice daily for 7 days (OCA regime). Endoscopy with rapid urease test, histology and culture were performed before treatment. Post-treatmentH. pyloristatus was determined by13C-urea breath test. Metronidazole, clarithromycin and amoxicillin resistance was defined as minimum inhibitory concentration (MIC) of>8 μg/mL,>1 μg/mL and>1 μg/mL, respectively.: A significantly higher (intention-to-treat/per-protocol) eradication rate was found in patients with duodenal ulcer than those with non-ulcer dyspepsia (91/94% vs. 84/88% respectively,P = 0.011 andP = 0.016). Clarithromycin resistance rate was higher in patients with non-ulcer dyspepsia than those with duodenal ulcer (14% vs. 6%,P = 0.015). Clarithromycin resistance (40% vs. 5%,P < 0.001, OR 12, 95% CI: 5.7–24.3) and the diagnosis of non-ulcer dyspepsia (91% vs. 84%,P = 0.011, OR 2.0, 95% CI: 1.2–3.3) significantly affected the success ofH. pylorieradication.: Clarithromycin resistance accounts for the significantly lower and suboptimalH. pylorieradication rate of OCA regimen in Chinese patients with non-ulcer dyspepsia compared to those with duodenal ulcer. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
