Immunity after COVID-19 and vaccination: follow-up study over 1 year among medical personnel.

Autor: Glück, Vivian, Grobecker, Sonja, Köstler, Josef, Tydykov, Leonid, Bertok, Manuela, Weidlich, Tanja, Gottwald, Christine, Salzberger, Bernd, Wagner, Ralf, Zeman, Florian, Koller, Michael, Gessner, André, Schmidt, Barbara, Glück, Thomas, Peterhoff, David
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Zdroj: Infection; Apr2022, Vol. 50 Issue 2, p439-446, 8p, 5 Graphs
Abstrakt: Background: The long-term course of immunity among individuals with a history of COVID-19, in particular among those who received a booster vaccination, has not been well defined so far. Methods: SARS-CoV-2-specific antibody levels were measured by ELISA over 1 year among 136 health care workers infected during the first COVID-19 wave and in a subgroup after booster vaccination approximately 1 year later. Furthermore, spike-protein-reactive memory T cells were quantified approximately 7 months after the infection and after booster vaccination. Thirty healthy individuals without history of COVID-19 who were routinely vaccinated served as controls. Results: Levels of SARS-CoV-2-specific IgM- and IgA-antibodies showed a rapid decay over time, whereas IgG-antibody levels decreased more slowly. Among individuals with history of COVID-19, booster vaccination induced very high IgG- and to a lesser degree IgA-antibodies. Antibody levels were significantly higher after booster vaccination than after recovery from COVID-19. After vaccination with a two-dose schedule, healthy control subjects developed similar antibody levels as compared to individuals with history of COVID-19 and booster vaccination. SARS-CoV-2-specific memory T cell counts did not correlate with antibody levels. None of the study participants suffered from a reinfection. Conclusions: Booster vaccination induces high antibody levels in individuals with a history of COVID-19 that exceeds by far levels observed after recovery. SARS-CoV-2-specific antibody levels of similar magnitude were achieved in healthy, COVID-19-naïve individuals after routine two-dose vaccination. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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