Synthesis and Antimicrobial Activity of Some New Spiropyrazoline Derivatives of 9α‐ and 9β‐Hydroxyparthenolide.

Autor:	Moumou, Mohamed, Outahar, Fatima, Ourhzif, El‐Mahdi, Hannioui, Abdellah, Bouamama, Hafida, El Ammari, Lahcen, Saadi, Mohamed, Rakib, El Mostapha, Akssira, Mohamed
Předmět:	ANTI-infective agents DOUBLE bonds STEREOCHEMISTRY ANTIBACTERIAL agents ACYLATION X-ray diffraction
Zdroj:	ChemistrySelect; 3/22/2022, Vol. 7 Issue 11, p1-5, 5p
Abstrakt:	In the present study, we efficiently synthesized two new series of spiropyrazoline derivatives from 9α‐ and 9β‐hydroxyparthenolide (isolated from the aerial parts of Anvillea radiata). The compounds were obtained by modifications at the C−13 and C−9 positions via 1,3‐dipolar cycloaddition followed by O−H acylation at the C1−C10 using epoxidation with metachloroperoxybenzoic acid (m‐CPBA) followed by 1,3‐dipolar cycloaddition on the double bond α‐methylene‐γ‐lactones. The structures and stereochemistry of the cycloadducts were established by spectroscopic methods, including X‐ray diffraction data. Some compounds were tested for antibacterial activity. Several spiropyrazoline derivatives showed good to moderate activity against bacteria. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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