| Autor: |
Kato, Tomotaka, Kudo, Atsushi, Kinowaki, Yuko, Ishikawa, Yoshiya, Watanabe, Shuichi, Akahoshi, Keiichi, Ogawa, Kosuke, Ono, Hiroaki, Ban, Daisuke, Tanaka, Shinji, Tanabe, Minoru |
| Předmět: |
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| Zdroj: |
Journal of Cancer Research & Clinical Oncology; Apr2022, Vol. 148 Issue 4, p931-941, 11p |
| Abstrakt: |
Purpose: To elucidate whether portal venous tumor invasion (PVTI) is a prognostic factor for patients with pancreatic neuroendocrine neoplasms (Pan-NENs). Methods: From 2002 to 2019, 240 patients with Pan-NEN were included to examine prognostic factors. PVTI based on computed tomography (CT) images are classified into four types: no PVTI (Vp0/1), PVTI not invading the superior mesenteric vein (Vp2), PVTI invading the superior mesenteric vein or portal vein (Vp3), and PVTI invading the portal bifurcation (Vp4). Results: Simultaneous liver metastases (SLM) determined the overall survival (OS) in 240 patients. The 5-year OS rates with and without SLM were 46% and 92%, respectively (P < 0.001). PVTIs were observed in 56 of the 240 patients (23%). Among such patients, 39, 11, and 6 had Vp2, Vp3, and Vp4, respectively. The 5-year OS rates with and without PVTI were 62% and 82%, respectively (P < 0.001). Severity of PVTI did not decide PFS and OS after R0/1 resection. There was significant difference in the prognoses between Vp0/1 and Vp2–4. In 161 patients without SLM, 21 had PVTI (13%). According to a multivariate analysis, PVTI and Ki-67 index were independent prognostic factors for progression-free survival (PFS) in patients without SLM. The 5-year PFS rates with and without PVTI were 18% and 77%, respectively (P < 0.001). The 5-year OS rates with and without PVTI were 76% and 95%, respectively (P = 0.02). PVTI was associated with tumor functionality, high serum NSE, and high Ki-67 index. Conclusions: PVTI may be a predictor for postoperative recurrence. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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