Long-term outcomes and prognostic factors affecting survival after pulmonary metastasectomy in solid tumors of childhood: A single center experience.

Autor:	Gaikwad, Vivek, John, Rikki, Karuppusami, Reka, K. Jacob, Tarun, Mathew, Leni, Kurian, Jujju
Předmět:	EVALUATION of medical care SPECIALTY hospitals ACQUISITION of data methodology OSTEOSARCOMA METASTASIS LUNG tumors RETROSPECTIVE studies TUMORS in children CANCER patients CANCER treatment NEPHROBLASTOMA MEDICAL records SURVIVAL analysis (Biometry) DESCRIPTIVE statistics LONGITUDINAL method EVALUATION
Zdroj:	Journal of Indian Association of Pediatric Surgeons; Mar/Apr2022, Vol. 27 Issue 2, p163-172, 10p
Abstrakt:	Introduction: This study assessed the long-term survival and the prognostic variables affecting survival following pulmonary metastasectomy (PM) secondary to childhood solid tumors. Materials and Methods: A retrospective analysis was done on 22 children who underwent PM for solid tumors between January 2007 and February 2020. The overall survival (OS) and event-free survival (EFS) at the end of the study period were noted. Tumor histology, completeness of resection, disease-free interval, laterality, location, number, and size of lung nodules were assessed for their significance in contributing to survival. Results: High-grade osteosarcoma (54.5%), followed by Wilms' tumor (18.2%), was the most common histological types. Unilateral nodules (59.1%) situated in a peripheral, sub-pleural location (91%) were the most common presentation. Pleural extension was noted in 12 (54.5%) patients. Synchronous pulmonary metastases were noted in 12 (54.5%) patients. Two developed metastases while undergoing chemotherapy and eight after the completion of therapy. The EFS and OS were both 31.8% at a median follow-up of 15.5 months (range 3–129 months). The median time required for an event to occur was 4 months (95% confidence interval [CI]: 1.4, 6.6 months) and median post-PM survival interval was 17 months (95% CI: 6.6, 27.4 months). Significant association was noted between preoperative tumor response to chemotherapy (P = 0.002) and survival. Conclusion: PM can improve survival in a select group of children with metastatic solid tumors. Favorable tumor response to chemotherapy was found to be a significant prognostic factors influencing survival. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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