Iodine promoted synthesis of pyrido[2′,1′:2,3]imidazo[4,5-c]quinoline derivatives via oxidative decarboxylation of phenylacetic acid.

Autor:	Jinkala, Rajesh, K. B., Shiva Kumar, Rapolu, Venkateshwarlu, Satish P., Nikumbh, Jammula, Subba Rao, Vidavalur, Siddaiah, Hindupur, Ramamohan, Tadiparthi, Krishnaji, Raghunadh, Akula
Předmět:	PHENYLACETIC acid QUINOLINE derivatives DECARBOXYLATION IODINE ISOQUINOLINE QUINOLINE RING formation (Chemistry)
Zdroj:	Synthetic Communications; 2022, Vol. 52 Issue 2, p258-267, 10p, 5 Diagrams, 1 Chart, 1 Graph
Abstrakt:	An unprecedented and efficient molecular iodine promoted domino protocol for the synthesis of N polycyclic pyrido[2′,1′:2,3]imidazo[4,5-c]quinolines were reported from phenylacetic acid and 2-(imidazoheteroaryl)anilines. This methodology was also extended for the preparation of benzo[4′,5′]thiazolo [2′,3′:2,3]imidazo[4,5-c]isoquinolines in good yields. However, this protocol proceeds via a sequential decarboxylation of phenylacetic acid with I2/DMSO system followed by Pictet-Spengler cyclization in good yields. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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