| Autor: |
BHATTACHARJEE, DEVANJALI, MOIN, AFRASIM, NAYAK, NIRMALA, S., PREETHI, S., MEENAKSHI, SIDDARAMAIAH, K. S., NITHIN, GOWDA, D. V. |
| Předmět: |
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| Zdroj: |
International Journal of Pharmaceutical Research (09752366); Jan-Mar2021, Vol. 13 Issue 1, p3450-3465, 16p |
| Abstrakt: |
Aim: The aim of the present study was to formulate the self-micro emulsifying dispersible tablets of Ibuprofen (IB) and promote the dissolution and bioavailability of ibuprofen. Methods: Badam Gum (BG) was added as a adsorbent into optimized liquid self-micro emulsifying drug delivery system (SMEDDS) of ibuprofen to prepare Solid self-micro emulsifying dispersible tablets dispersible tablets by wet granulation method. Results: The composition of optimized liquid IB SMEDDS contains 17 % of Labrafil M was oil state, 28% of Cremophor EL as surfactant and 9.34% of PEG 400 as Co surfactant based on the result of Solubility test, selfemulsifying grading test, droplet size analysis, and ternary phase diagrams. Badam gum was added as a adsorbent into the optimized liquid IB-SMEDDS formulation to prepare the dispersible tablets by wet granulation compression method. The absorption capacity of silica (insoluble material) was higher (2.9g/g) than that of BG (0.9 g/g) (soluble material). Percent of IB released from silica within 45 min was less than 78%, while the percent of IB released from BG was 97.12%. In vitro reconstitution study confirmed the IB SMEDDS dispersible tablets had good quality. SEM images exhibited that the prepared IB-SMEDDS dispersible tablet had no effect on the morphology of the emulsion droplet of the SMEDDS system. Conclusion: In conclusion, this study would help to the application of the solid self-micro emulsifying technology to enhance solubility and dissolution of poorly water-soluble drug like Ibuprofen. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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