| Autor: |
JAMEEL, DALYA ABDULSATTAR, FARAJ, FADHIL LAFTA, ALI, WASSAN BAQIR |
| Předmět: |
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| Zdroj: |
International Journal of Pharmaceutical Research (09752366); 2020 Supplement1, p755-760, 6p |
| Abstrakt: |
Series of new indole based Schiff base derivatives were designed and synthesized by reacting 2-(1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene) malonaldehyde with different substituted aniline. The chemical structure of the compounds were confirmed and characterized by spectroscopic techniques (FT-IR, 1H-NMR and APT 13C-NMR). The target compounds with different concentrations were screened for their cytotoxicity activity against AMJ-13 breast cancer cell line. The results showed that compounds have promising cytotoxicity activity against AMJ13 cell line particularly compound (3) showed highest inhibition at 100 µg/ml rate among the tested compounds with variety concentrations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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