Endoscopic radiofrequency ablation may improve overall survival in patients with inoperable ampullary carcinoma.

Autor: Xia, Ming‐Xing, Shi, Zhi‐Mei, Xing, Ling, Gao, Dao‐Jian, Ye, Xin, Wang, Tian‐Tian, Wu, Jun, Qian, You‐Wen, Qin, Wen‐Hao, Hu, Bing
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Zdroj: Digestive Endoscopy; Mar2022, Vol. 34 Issue 3, p587-595, 9p
Abstrakt: Objectives: Patients with advanced ampullary carcinoma (AC) who are unsuitable for surgery are most likely to have poor outcomes. The role of endoscopic radiofrequency ablation (RFA) in this population has not been fully defined. We aimed to assess the short‐ and long‐term outcomes of RFA in a large cohort of AC patients. Methods: In this retrospective study, data of consecutive patients with pathologically proven AC who underwent successful endobiliary RFA and/or stent placement were collected. All patients did not undergo surgical resection. The primary outcome was overall survival (OS). The secondary outcomes included clinical success and adverse events. Results: A total of 85 patients, 50 in the RFA plus stenting group and 35 in the stenting alone group, were identified. The median OS was significantly longer in the RFA group than in the stenting alone group (16.9 vs. 9.8 months, P < 0.001). In multivariable Cox analysis, RFA (hazards ratio 0.408; 95% confidence interval 0.235–0.706; P = 0.001) was the only independent OS predictor. Eight patients with stage II tumors, exclusively from the RFA group, survived for more than 3 years. Clinical success was comparable between the two groups (96% vs. 100%, P = 0.231). Early adverse events between the two groups were similar (10% vs. 2.9%, P = 0.206); however, late biliary/pancreatic stenoses occurred in three RFA patients who were successfully managed with endoscopic interventions. Conclusions: Endoscopic RFA appears to prolong patients' survival with acceptable safety; it may therefore be a feasible treatment option for patients with inoperable ampullary cancers. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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