Effectiveness of a new rutin Cu(II) complex in the prevention of lipid peroxidation and hepatotoxicity in hypercholesterolemic rats.

Autor: de Oliveira, Daniel A. F., Diniz, Susana N., Pereira, Regina M. S., Gonçalves, Ivair D., Rennó, André L., Gorjão, Renata, Vieira, Eduardo G., da C. Ferreira, Ana M., Okuyama, Cristina E.
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Zdroj: Journal of Food Biochemistry; Mar2022, Vol. 46 Issue 3, p1-15, 15p
Abstrakt: A new rutin copper(II) complex (R‐Cu2) was prepared and characterized by spectroscopic methods and elemental analysis. The effects of rutin and R‐Cu2 were evaluated on the prevention of hypercholesterolemia in animals feed with high‐cholesterol diet (HCD) for 8 weeks. The animals (n = 5) were neither fed with HCD nor treated (control group), or were treated with vehicle, 10 mg/kg simvastatin, rutin (16 and 160 μmol/kg), and R‐Cu2 (16 and 160 μmol/kg) administered orally. Total cholesterol (TC) levels were significantly increased (p <.01) in all HCD groups. In rutin and R‐Cu2 groups, it was observed a discrete, but not significant, TC and LDL‐induced increase inhibition compared with vehicle‐treated group. R‐Cu2 treatment significantly decreased (p <.05) plasma triglycerides compared with the vehicle‐treated group. All groups receiving treatments maintained the malondialdehyde at normal levels. Serum NO levels were reduced in animals treated with rutin and R‐Cu2 compared with the vehicle‐treated group. In addition, the results also showed that the groups treated with rutin and R‐Cu2 reduced significantly (p <.01), the number of neutrophils and prevented histological changes in all evaluated liver zones. R‐Cu2 group maintained the ALT, AST, and ALP enzymes at normal levels. Thus, the effects of R‐Cu2 in modulating inflammation and protecting liver damage were confirmed. Practical applications: Rutin, a plant‐derived flavonoid, is one of phenolic compounds well known as a nutraceutical due to its antioxidant and anti‐inflammatory properties. Findings of this study demonstrate the effects of both rutin and R‐Cu2 in modulating inflammation and protecting liver damage in hypercholesterolemic rats. However, some effects analyzed became more evident in R‐Cu2. Thereby, it was shown that the synthesis of a new flavonoid compound (R‐Cu2) could be applied as a nutraceutical benefit option to prevent hypercholesterolemia condition. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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