| Autor: |
Ozgu-Erdinc, A. Seval, Gozukara, Ilay, Kahyaoglu, Serkan, Yilmaz, Saynur, Yumusak, Omer Hamit, Yilmaz, Nafiye, Erkaya, Salim, Engin-Ustun, Yaprak |
| Předmět: |
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| Zdroj: |
Hormone Molecular Biology & Clinical Investigation; Mar2022, Vol. 43 Issue 1, p35-40, 6p |
| Abstrakt: |
Studies have established a relationship between proinflammatory factors and implantation failure in IVF/ICSI cycles. Likewise, low-grade chronic inflammation is generally blamed for predisposing infertility. In the present study, we aimed to find a relationship between serum IL-6 and hs-CRP levels and IVF/ICSI cycle outcomes. A total of 129 patients who consented to participate and attended the IVF unit of our department for the treatment of infertility have been enrolled in this prospective cohort study. Serum levels of high sensitive C-reactive protein and interleukin 6 have been detected at the beginning of the IVF/ICSI ovulation induction cycle. Cycle outcomes have been compared between patients with and without clinical pregnancy achievement following ART treatments. IVF/ICSI cycle outcomes of these two groups were also comparable except the number of >14 mm follicles, retrieved oocytes, metaphase II oocytes, and fertilized oocytes (2 pronuclei) which were in favor of the clinical pregnancy group. Mean serum hs-CRP levels were 3.08 mg/L (0.12–35.04) and 2.28 mg/L (0.09–22.52) patients with and without clinical pregnancy respectively. Mean serum IL-6 levels were 2 pg/mL (1–10.2) and 2 pg/mL (1–76.9) patients with and without clinical pregnancy respectively. Both tests were found to be statistically insignificant in predicting the success of the ART cycle in terms of implantation, clinical pregnancy, miscarriage, and live birth. In the present study, we have not found any significant effect of hs-CRP and IL-6 levels in the IVF cycle. However, in the light of this and previous studies, large-scale research may prove the exact influence of these markers on IVF success. – There is an equilibrium between pro-and anti-inflammatory factors during the regulation of reproduction. – Chronic low-grade inflammation has been found to be present in many reproductive dysfunctions. – However in the present study we have not found any significant effect of hs-CRP and IL-6 levels in IVF cycle. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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