| Autor: |
KARIMI, Hasiba, MAHFOOZ, Sadaf, KHAN, Imran, KARAÇAM, Büşra, AKDUR, Kerime, GÖNEN, Güven, ŞAKARCAN, Ayten, ÇAVUŞOĞLU, Merve, ELBASAN, Burçe, HATİBOĞLU, Mustafa Aziz |
| Předmět: |
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| Zdroj: |
Bezmialem Science; 2022 Suppl, Vol. 10, pS12-S12, 1p |
| Abstrakt: |
Introduction: Meningiomas are the most common primary brain tumors in adults. The diagnosis of meningioma can be made using magnetic resonance imaging of brain. However, there are difficulties differentiating the grades of the tumor, which is important for choosing the right treatment (follow, surgical resection, Gamma Knife) and extent of tumor resection if surgery is preferred. However, there is no established method for meningioma grading. Although the expression of c-MYC, FABP7, GATA4, and MAOB have been investigated in meningioma tissues, their expression in serum has not been described. Therefore, this study aimed to evaluate the role of liquid biopsy by investigating the expression of these genes in meningioma patients. Method: Twenty patients who underwent surgical resection of intracranial meningiomas were enrolled. Tumor and serum samples were obtained during the surgery. Real time polymerase chain reaction was performed to assess the expression of FABP7, GATA-4, c-MYC, and MAOB in tumor tissue and in serum. Patients' clinical data including age, gender, radiological findings, simpson grade were retrospectively collected. Results: The expression levels of FABP7 and MAOB in serum of meningioma patients were significantly higher than healthy controls (p<0.05). The expression levels of MAOB in serum of grade 2 meningioma were significantly higher than those with grade 1 (p=0.032). MAOB, c-MYC and GATA4 genes were expressed significantly higher (p=0.031, p=0.041, p=0.003, respectively) in tumor tissues from grade 2 meningioma patients compared to grade 1. We did not observe any of these genes to be correlated with patients' clinical data and local tumor control. Conclusion: Our results suggested that expressions of FABP7 and MAOB genes in serum could be implemented as diagnostic marker for meningiomas. However, further studies are required. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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