| Autor: |
Kotha Lakshmi Narayan, Poornima, Readler, James M., Alghamri, Mahmoud S., Brockman, Trisha L., Yan, Ran, Sharma, Priyanka, Snitsarev, Vladislav, Excoffon, Katherine J. D. A., Kolawole, Abimbola O. |
| Předmět: |
|
| Zdroj: |
Pathogens; Feb2022, Vol. 11 Issue 2, p173, 1p |
| Abstrakt: |
The coxsackievirus and adenovirus receptor (CAR) is an essential cellular protein that is involved in cell adhesion, cell signaling, and viral infection. The 8-exon encoded isoform (CAREx8) resides at the apical surface of polarized epithelia, where it is accessible as a receptor for adenovirus entering the airway lumen. Given its pivotal role in viral infection, it is a target for antiviral strategies. To understand the regulation of CAREx8 and determine the feasibility of receptor downregulation, the half-life of total and apical localized CAREx8 was determined and correlated with adenovirus transduction. Total and apical CAREx8 has a relatively short half-life of approximately 2 h. The half-life of apical CAREx8 correlates well with adenovirus transduction. These results suggest that antiviral strategies that aim to degrade the primary receptor for apical adenovirus infection will be effective within a relatively short time frame after application. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
