| Abstrakt: |
Acute toxicity of noncovalent nanocomplex of C60 fullerene with Cisplatin (Cis-Pt) (the ratio of compounds C60:Cis-Pt by weight 1:1) in a dose progression (7.5 + 7.5, 15.0 + 15.0, 22.5 + 22.5, 30.0 + 30.0, 37.5 + 37.5, and 45.0 + 45.0 mg/kg) was investigated in mice of BALB/c line. Mice were injected with C60–Cis-Pt nanocomplex or free Cis-Pt at the same doses single intraperitoneally and observed for 14 days. A comparative study of the toxicity of free Cis-Pt and Cis-Pt at noncovalent complexation with C60 fullerene (C60–Cis-Pt nanocomplex) demonstrated halving the toxicity of C60–Cis-Pt nanocomplex in comparison with free Cis-Pt: LD50 (Cis-Pt) 15.6 ± 1.3 mg/kg vs LD50 (C60–Cis-Pt) 36.1 ± 2.8 mg/kg. The toxic effects of C60–Cis-Pt nanocomplex and free Cis-Pt were detected at doses 22.5 + 22.5 mg/kg and 15.0 mg/kg, respectively, and were accompanied by impaired mice behavior, decreased body weight and animal survival, hematotoxicity, and pathological changes in heart, liver, spleen, and kidneys. It was shown that C60 fullerene complexed with Cis-Pt prevented drug-induced decrease in animal survival, anemia, thrombocytosis, and leukopenia development, as well as inflammatory processes in spleen, heart, kidney, and liver. The obtained results indicate the prospects for using noncovalent nanocomplex C60–Cis-Pt in antitumor therapy at low therapeutic doses of Cis-Pt. [ABSTRACT FROM AUTHOR] |
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