Histopathological prognosis of papillary thyroid carcinoma associated with nutritional status of vitamins A and E.

Autor:	Lima-Antoine, Lara, de Sousa Alves Neri, Julianna Lys, de Melo, Thaisa Cristina Tavares, Leite, Isabela Samária Fernandes, da Costa Santos, Diego Marques, de Araújo, Jéssica Nayara Góes, da Costa Lemos Silva, Ana Gabriella, de Araújo, Nathália Kelly, de Oliveira Ramos, Carlos C., de Miranda Henriques Tarrapp, Sheila Ramos, Luchessi, Andre Ducati, de Oliveira Lyra, Clélia, da Silva Ribeiro, Karla Danielly, Silbiger, Vivian Nogueira
Předmět:	VITAMINS RESEARCH THYROID gland tumors CROSS-sectional method RESEARCH methodology RETROSPECTIVE studies PROGNOSIS EVALUATION research COMPARATIVE studies VITAMIN A RESEARCH funding NUTRITIONAL status
Zdroj:	European Journal of Clinical Nutrition; Mar2022, Vol. 76 Issue 3, p469-476, 8p
Abstrakt:	Background/objectives: Experimental and clinical studies have shown that vitamins A and E can inhibit cancer formation and progression. The unfavourable status of these vitamins can represent risk factors for the disease. This study aimed to evaluate the associations between the nutritional status of vitamins A and E (serum levels and dietary intake) and histopathological outcomes in Papillary Thyroid Carcinoma (PTC) patients.Subjects/methods: We applied a cross-sectional study (2017-2018) and quantified retinol (ROH) and α-tocopherol (TOH) serum levels and vitamins dietary intake of 46 PTC patients. Serum vitamins were quantified by high efficiency liquid chromatography and vitamins dietary intake was analyzed by 24-hr dietary recalls.Results: Patients with lower ROH serum levels were more likely to present lymph node metastasis and/or angiolymphatic invasion (p = 0.025). In addition, higher vitamin A and vitamin E intake are related to the absence of extrathyroidal extension (p = 0.013) and lymph node metastasis (p = 0.007), respectively. Our findings suggest that a ROH serum level greater than 2.65 μmol/L in PTC patients may be a protective factor against the presence of lymph node metastasis and angiolymphatic invasion. In addition, vitamin A and E intake may protect against extrathyroidal extension and lymph node metastasis.Conclusions: A favourable nutritional status (higher serum levels and/or intake) of vitamin A and E may be associated with less aggressive tumours in PTC patients. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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