Використання стимуляційних маркерів для аналізи терапевтичного впливу С60-фуллерену на динаміку м’язового скорочення хронічно-алкоголізованих щурів.

Autor: Ноздренко, Д. М., Нан, Ванг, Мотузюк, О. П., Виговська, О. В., Богуцька, К. І., Дрозд, П. Ю., Прилуцький, Ю. І.
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Zdroj: Nanosistemi, Nanomateriali, Nanotehnologii; 2021, Vol. 19 Issue 3, p767-777, 11p
Abstrakt: The effect of C60 fullerene aqueous solution on the dynamic parameters of skeletal muscle contraction of chronic alcoholic rats with duration of alcoholization of 2, 4 and 6 months is studied. C60 fullerene at a dose of 1 mg/kg is administered intraperitoneally during the last five days of alcoholization. Changes in the time of onset of muscle strength response are used as a marker to assess the level of myocyte damage and the severity of alcoholization in experimental animals. A pronounced protective effect of C60 fullerene aqueous solution on the dynamics of muscle contraction with the development of alcoholic myopathy in animals is revealed that allows its use as a principally new drug in the treatment of muscle pathologies. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index