Insulin action in subjects with type 2 diabetes following biliopancreatic diversion.

Autor: Papadia, Francesco, Carlini, Flavia, Rubartelli, Alice, Battistini, Micaela, Cordera, Renzo, Adami, Gian Franco, Camerini, Giovanni
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Zdroj: European Journal of Clinical Investigation; Apr2022, Vol. 52 Issue 4, p1-4, 4p
Abstrakt: This brief report aimed to indirectly assess the insulin resistance and the insulin secretion before biliopancreatic diversion (BPD) and at five and ten years after the operation in a clinical sample of T2DM overweight and class 1 obesity patients. Keywords: bariatric/metabolic surgery; insulin action; type 2 diabetes EN bariatric/metabolic surgery insulin action type 2 diabetes 1 4 4 03/11/22 20220401 NES 220401 INTRODUCTION In obese subjects with type 2 diabetes (T2DM), bariatric surgery is followed in most cases by a stable metabolic improvement, with complete T2DM remission or a satisfactory T2DM control.1 Bariatric surgery causes by itself a marked and well-maintained weight loss: this entails a sharp decrease of insulin resistance and therefore an improvement of metabolic status.1,2 On the contrary, just after bariatric surgery, a marked increase in insulin secretion develops, which persists for years after the operation3: the postoperative rearrangement of the upper gastrointestinal tract causes increase in GLP-1 production and then enhancement of insulin secretion,4 ensuing in a reduction of lipotoxicity and glycotoxicity with a consequent beta-cell-deficit restoring, that warrants positive metabolic outcomes at long term. [Extracted from the article]
Databáze: Complementary Index
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