| Autor: |
Sen, Souvik, An, Hongyu, Sollman, Myriam, Oakes, Jonathan, Eron, Joseph, Robertson, Kevin, Powers, William |
| Předmět: |
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| Zdroj: |
European Journal of Neurology; Apr2022, Vol. 29 Issue 4, p1062-1074, 13p |
| Abstrakt: |
Background and purpose: Regional cerebral blood flow (rCBF) and oxygen metabolism (rCMRO2) in whole brain, white matter, gray matter and lenticular nuclei were studied in people living with human immunodeficiency virus (PLHIV) as well as HIV‐associated neurocognitive disorder (HAND). Methods: Treatment‐naïve PLHIV underwent neurocognitive assessment and magnetic resonance (MR) measurement of rCBF and rCMRO2 with repeat after 12 months of antiretroviral therapy (ART). Age‐ and sex‐matched controls underwent single MR measurements. Regional CBF and rCMRO2 were compared amongst symptomatic, asymptomatic, normal HAND and controls using analysis of variance. Longitudinal analysis of HAND worsening (≥1 category) was assessed after 12 months of ART and correlated with rCBF and rCMRO2 measured by MR imaging using the paired‐sample t test. Results: Thirty PLHIV completed baseline and 12‐month assessments (29 with rCMRO2 measurement). At baseline HAND assessment, 13% had no cognitive impairment, 27% had asymptomatic neurocognitive impairment, 60% had mild neurocognitive disorder and none had HIV‐associated dementia. At 12 months, 13% had no cognitive impairment, 20% had asymptomatic neurocognitive impairment, 50% had mild neurocognitive disorder and 17% had HIV‐associated dementia. In those without HAND worsening (N = 21) rCMRO2 remained stable and in those with HAND worsening (N = 8) rCMRO2 measurement declined from baseline to 12 months in white matter (2.05 ± 0.40 to 1.73 ± 0.51, p = 0.03) and lenticular nuclei (4.32 ± 0.39 to 4.00 ± 0.51, p = 0.05). Conclusions: In recently diagnosed PLHIV, no association was found between rCBF or rCMRO2 and cognitive impairment at baseline. There was a reduction in rCMRO2 in those with worsening of cognitive function at 12 months on ART. Reduction in rCMRO2 may be a biomarker of cognitive decline in PLHIV. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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