| Autor: |
Olszowski, Tomasz, Milona, Marta, Janiszewska‐Olszowska, Joanna, Safranow, Krzysztof, Uzar, Izabela, Walczak, Alicja, Sikora, Maciej, Chlubek, Dariusz, Adler, Grażyna |
| Předmět: |
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| Zdroj: |
Oral Diseases; Apr2022, Vol. 28 Issue 3, p771-776, 6p, 3 Charts |
| Abstrakt: |
Objective: To examine the association of four FCN1 SNPs: −542G>A (rs10120023), −144C>A (rs10117466), +6658C>T (rs148649884), and +7895A>G (rs150625869) with dental caries in Polish children. Subjects and Methods: The study group consisted of 261 15‐year‐old Polish teenagers: 82 children with "higher" caries experience (having Decayed Missing Filled Teeth, DMFT >5) and 179 children with "lower" caries experience (having DMFT ≤5). Moreover, in additional comparison, a group of 229 children with caries experience (DMFT ≥1) was compared to a caries‐free (DMFT =0) group of 32 children. Extraction of genomic DNA was performed from buccal swabs, and genotyping was performed by Real‐Time PCR. Results: FCN1 SNPs +6658C>T and +7895A>G appeared to be monomorphic in our sample. The genotype, allele, or haplotype distributions in FCN1 SNPs −542G>A and −144C>A in children with "higher" caries experience did not differ significantly from those in "lower" caries experience group. Similar results with no significant differences were demonstrated for subjects with DMFT ≥1 compared to subjects with DMFT =0. Conclusion: FCN1 SNPs are not the markers of dental caries susceptibility in Polish children. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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