| Autor: |
Woods, Robbie S. R., Callanan, Deirdre, Jawad, Hadeel, Molony, Peter, Werner, Reiltin, Heffron, Cynthia, Feeley, Linda, Sheahan, Patrick |
| Předmět: |
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| Zdroj: |
European Archives of Oto-Rhino-Laryngology; Mar2022, Vol. 279 Issue 3, p1435-1443, 9p |
| Abstrakt: |
Purpose: The precise etiopathogenesis of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC), and reasons for predilection for crypt epithelium, remain uncertain. The purpose of this study is to investigate the interaction between HPV and specific cytokeratins 7 (CK7) and 19 (CK19) in crypt epithelium. Methods: This is a retrospective cohort study of patients presenting between 1999 and 2015 at a tertiary referral center. CK7 and CK19 positivity and H Scores were determined by immunohistochemistry. Disease-specific and overall survival rates were analyzed. Results: There were 253 patients presenting with OPSCC (134), squamous cell carcinoma (SCC) of unknown primary site (22), and oral tongue SCC (97). Primary tumor CK7 and CK19 positivity and H Scores were significantly higher in HPV-positive OPSCC than HPV-negative OPSCC and oral tongue SCC. Higher CK19 Scores, but not CK7 Scores, were also seen in regional metastases from HPV-positive OPSCC than other sites. No impact on disease-specific or overall survival was identified on multivariate analysis. Conclusion: The increased expression of CK7 and CK19 in HPV-positive OPSCC compared to HPV-negative disease supports the theory for a role for these cytokeratins in the etiopathogenesis of HPV-related OPSCC. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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