| Abstrakt: |
The key role of protein-based nanoparticles has revolutionized the present technology. The development of drug delivery systems that use protein nanoparticles as carriers for drug molecules keeps on being a fast-growing field of study. In particular, the protein NPs present a number of advantages as drug carriers, which can be listed as their abundance in natural resources, biocompatibility, easy synthesis process, and cost effectiveness. Protein nanoparticles also have extraordinary biodegradability and non-antigenic properties. Moreover, they have attracted attention substantially as they have surface modification flexibility during drug addition. Natural biomolecules, like proteins, constitute an attractive alternative to synthetic polymers used widely in drug formulations, thanks to numerous advantages specified above. In particular, the fact that the Human Serum Albumin protein has a capacity of carrying drugs to a very large extent was considered highly attractive by scientists in their studies in view of the synthesis of drug-loaded nanoparticles. In this study, the objective was set to design the constitution of a drug carrying system against a specific disease (in bacterial infection treatments). LC, FT-IR Spectrophotometer, and ZetaSizer were used to scrutinize the nanoparticles. A Scanning Electron Microscope was used for morphological scrutiny. Nanoparticle (NPs) yield, encapsulation efficiency, and drug loading capacity were identified and in vitro release of the drug was pored over. [ABSTRACT FROM AUTHOR] |
