| Autor: |
Alina Romanenko, Luisa Morell-Quadreny, Jose Antonio Lopez-Guerrero, Antonio Pellin, Valentin Nepomnyaschy, Alexander Vozianov, Antonio Llombart-Bosch |
| Předmět: |
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| Zdroj: |
Virchows Archiv: European Journal of Pathology; Sep2004, Vol. 445 Issue 3, p298-304, 109p |
| Abstrakt: |
Previous studies have shown that during the period subsequent to the Chernobyl accident, increases in morbidity, aggressivity and proliferative activity of renal-cell carcinomas (RCCs) in Ukrainian patients were recognized. The present paper describes the molecular alterations of those tumor suppressor genes located on chromosome 9p21 ( INK4a/ARF locus and p15 INK4B) in 26 primary renal-cell epithelial tumors from patients with different degrees of radiation exposure after the Chernobyl accident in Ukraine. Radiometric measurement of Cesium 137 ( 137Cs) was conducted with 1-day urine from all patients before surgery. Our results demonstrate that RCCs from patients living in the radio-contaminated areas showed aberrant hypermethylation of p14 ARF and p16 INK4A genes, associated with increased p38MAPK, p14 ARF, mdm2, cyclinD1 and Ki67 protein expression levels. Present findings show the possibility that chronic long-term low-dose radiation activates the INK4a/ARF locus, targeted by activation of the p38MAPK cascade. These actions could lead to disruptions and loss of cell cycle checkpoints and, thereby, to cellular transformation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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