Altered Polarization and Impaired Phagocytic Activity of Lung Macrophages in People With Human Immunodeficiency Virus and Chronic Obstructive Pulmonary Disease.

Autor:	Akata, Kentaro, Leung, Janice M, Yamasaki, Kei, Filho, Fernando S Leitao, Yang, Julia, Yang, Chen Xi, Takiguchi, Hiroto, Shaipanich, Tawimas, Sahin, Basak, Whalen, Beth A, Yang, Cheng Wei Tony, Sin, Don D, Eeden, Stephan F van, Leitao Filho, Fernando S, Xi Yang, Chen, van Eeden, Stephan F
Předmět:	HIV CHRONIC obstructive pulmonary disease MACROPHAGES LUNGS RESEARCH PHAGOCYTOSIS RESEARCH methodology EVALUATION research COMPARATIVE studies OBSTRUCTIVE lung diseases
Zdroj:	Journal of Infectious Diseases; 3/1/2022, Vol. 225 Issue 5, p862-867, 6p
Abstrakt:	Background: People with human immunodeficiency virus (PWH) have an increased risk of developing chronic obstructive pulmonary disease (COPD).Methods: We phenotyped lung macrophages in 4 subgroups-M1 (CD40+CD163-), M2 (CD40-CD163+), double positives (CD40+CD163+), and double negatives and (CD40-CD163-)-and we determined their phagocytic capacity in PWH with and without COPD.Results: People with human immunodeficiency virus with COPD have more double-negative macrophages (84.1%) versus PWH without (54.3%) versus controls (23.9%) (P=.004) and reduced phagocytosis (P=.012). Double-negative macrophages had the worst phagocytic capacity (P<.001).Conclusions: People with human immunodeficiency virus with COPD have an abundance of nonpolarized macrophages, which have poor phagocytic capacity and therefore predispose PWH to increased risk of disease progression. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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