| Autor: |
Olszewska, Berenika, Żawrocki, Anton, Gleń, Jolanta, Lakomy, Joanna, Karczewska, Joanna, Zabłotna, Monika, Malek, Marta, Jankau, Jerzy, Lange, Magdalena, Biernat, Wojciech, Nowicki, Roman J., Sokołowska-Wojdyło, Małgorzata |
| Předmět: |
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| Zdroj: |
Advances in Dermatology & Allergology / Postępy Dermatologii i Alergologii; 2022, Vol. 39 Issue 1, p81-87, 7p |
| Abstrakt: |
Introduction: Cutaneous T-cell lymphomas (CTCL) are malignant lymphoproliferative disorders accompanied by persistent pruritus. Pruritogenic role of interleukin-31 (IL-31) has been studied extensively and was proven in atopic dermatitis (AD), while its role in CTCL is still rather vague. Aim: To investigate IL-31 serum level along with IL-31, IL-31 receptor α (IL-31RA) and oncostatin M receptor β (OSMR) skin expression in CTCL and compare it to controls: AD and healthy volunteers. Material and methods: The level of IL-31 in serum was measured using ELISA, while IL-31 and receptors' expression in the skin were measured using immunohistochemistry and correlated with the stage of disease and pruritus severity. Results: Expression of IL-31 and IL-31 receptor in serum and skin were significantly higher in CTCL and AD in comparison to healthy controls. No significant correlation between the IL-31 serum level and pruritus severity in CTCL patients was found. There was also no correlation between IL-31/IL-31RA/OSMR expression in the skin and CTCL pruritus, while IL-31 and IL-31RA in CTCL skin negatively correlated with the stage of disease. Conclusions: Our data indicate that IL-31 does not play a crucial role in pruritus in CTCL but it is rather involved in the pathogenesis of the disease. It seems that IL-31 plays an essential role in the pruritus pathomechanism that is unique to AD. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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