| Autor: |
Camacho-Barcia, Lucía, García-Gavilán, Jesús, Martínez-González, Miguel Ángel, Fernández-Aranda, Fernando, Galié, Serena, Corella, Dolores, Cuenca-Royo, Aida, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M, Wärnberg, Julia, Martínez, J Alfredo, Serra-Majem, Luís, Estruch, Ramón, Bernal-López, M Rosa, Lapetra, José, Pintó, Xavier, Tur, Josep A, Garcia-Rios, Antonio, Bueno-Cavanillas, Aurora |
| Předmět: |
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| Zdroj: |
Age & Ageing; Feb2022, Vol. 51 Issue 2, p1-7, 7p, 1 Chart, 1 Graph |
| Abstrakt: |
Background In the last years, evidence that dietary vitamin K could have a role in the cognitive domain has increased. However, data from large trials are limited. The objective of this study was to assess the association of 2 year changes in the dietary intake of vitamin K with cognitive function measured through neuropsychological performance tests. Methods In 5,533 participants of the multicentre PREDIMED-Plus study (48.1% women, age 65.1 ± 4.9 years with overweight/obesity and metabolic syndrome), we assessed the adjusted odds ratios of cognitive function decline according to 2 year changes in vitamin K intake. Participants answered a battery of cognitive function tests and Food Frequency Questionnaires (FFQs) in order to estimate the vitamin K dietary intake. Results After adjusting for potential cofounders, the highest tertile of change of dietary vitamin K intake (median [IQR]; 194.4 μg/d [120.9, 373.1]) was inversely associated with a Mini-Mental State Examination (MMSE) score ≤24 (OR [95% CI]; 0.53 [0.35, 0.79] P for trend = 0.002) compared with a decrease in the intake of vitamin K (median [IQR]; −97.8 μg/d [−292.8, −51.5]). A significant positive association between changes in dietary vitamin K intake and the semantic verbal fluency test scores (OR [95% CI]; 0.69 [0.51, 0.94] P for trend = 0.019) was found. Conclusions An increase of the intake of dietary vitamin K was associated with better cognitive function scores, independently of recognised risk factors for cognitive decline, in an older adult Mediterranean population with high cardiovascular risk. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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