In vivo study of anti-inflammatory and antinociceptive activities of Copaifera pubiflora Benth oleoresin.

Autor: Símaro, Guilherme Venâncio, Lemos, Marivane, Silva, Jonas Joaquim Mangabeira da, Cunha, Wilson Roberto, Carneiro, Luiza Junqueira, Ambrósio, Sérgio Ricardo, Cunha, Nayanne Larissa, de Andrade, Sérgio Faloni, Arruda, Caroline, Banderó-Filho, Vilmar C., Sasse, Astrid, Sheridan, Helen, Bastos, Jairo Kenupp, Silva, Márcio Luis Andrade e
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Zdroj: Natural Product Research; Feb2022, Vol. 36 Issue 4, p1129-1133, 5p
Abstrakt: Copaifera pubiflora Benth oleoresin (CPO) is used as an anti-inflammatory, wound healing, and antimicrobial. This paper reports the cytotoxic, anti-inflammatory, and antinociceptive activities of CPO. CPO (10 mg/kg) did not affect locomotor capacity in the open-field and rotarod tests and was not cytotoxic to CHO-k1, THP-1, and L929 cell lines. It was active in the formalin test at 3 mg/kg by 86 ± 3% and 96 ± 3%, respectively, for the first and second phases. At 10 mg/kg, CPO inhibited 90 ± 7%, the pain in the mechanical hyperalgesia test. In the tail-flick test, CPO at 3 mg/kg affected the tail-flick latencies in mice by 77 ± 20%, which in combination with naloxone was only partially reduced. At 3 mg/kg CPO inhibited 80 ± 12% the carrageenan-induced paw edema, and at 3 mg/kg it reduced by 91 ± 5% the nociception on acetic acid-induced abdominal writhing. Therefore, CPO possesses anti-inflammatory and antinociceptive activities. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index