| Autor: |
Nicolas, Marilou G., Javier, Lia Margret, Litan, Richard Ron R., Gonzaga, Alex, Punzalan, Jervee M. |
| Předmět: |
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| Zdroj: |
Philippine Journal of Science; Feb2022, Vol. 151 Issue 1, p13-23, 11p |
| Abstrakt: |
In the Philippines, one of every 54 newborns has glucose-6-phosphate dehydrogenase (G6PD) deficiency. While most were determined to have a familial origin, at least 15% of cases have unknown etiology. This study investigated sex, regional malaria incidence, and zinc deficiency as factors contributing to the high incidence of G6PD deficiency in Filipinos. The study used both retrospective and experimental approaches. The retrospective study analyzed demographic data reported in 8,158 clean archival records from 2010-2015 of 0-5-yr-old Filipino children with G6PD deficiency; the regional distribution data from DOH of malaria was also included for possible correlation with the regional frequency of malaria in the Philippines. The experimental approach determined plasma zinc concentrations of 138 deficient and 41 normal neonates and children aged 0-11 mo using atomic absorption spectroscopy to determine if the zinc level was associated with G6PD activity. Results showed that the major peak for G6PD activity for the male cluster was at 0.5-3.5 U/g Hb, while there were two major peaks for females - one at 0.5-2.5 U/g Hb and another at 3-9.5 U/g Hb. These results are consistent with G6PD-deficiency being an X-linked disorder and for Filipinos, a sex-based reference standard in the newborn screening for G6PD activity of Filipino children is, therefore, being proposed. The incidence of malaria in the country showed no association with G6PD incidence (p = 0.06; p = 0.983). On the other hand, the mean plasma zinc concentration of G6PD-deficient children aged 0.5-3 mo old at 43.11 ± 1.68 µg/dL was significantly different from that of normal controls at 51.89 ± 3.00 ug/dL. These results showed, therefore, that there is a probable association between zinc deficiency and the disorder in 0-3-mo-old children, implying mother's micronutrient health as a risk factor in the high prevalence of G6PD among Filipino children. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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