Kidney disease and COVID-19 disease severity—systematic review and meta-analysis.

Autor: Singh, Jagmeet, Malik, Preeti, Patel, Nidhi, Pothuru, Suveenkrishna, Israni, Avantika, Chakinala, Raja Chandra, Hussain, Maryam Rafaqat, Chidharla, Anusha, Patel, Harshil, Patel, Saurabh Kumar, Rabbani, Rizwan, Patel, Urvish, Chugh, Savneek, Kichloo, Asim
Předmět:
Zdroj: Clinical & Experimental Medicine; Feb2022, Vol. 22 Issue 1, p125-135, 11p
Abstrakt: We aimed to identify prevalence and association of comorbid chronic kidney disease (CKD), acute kidney injury (AKI) and utilization prevalence of continuous renal replacement therapy (CRRT) in COVID-19-hospitalized patients as a function of severity status. With the ongoing struggle across the globe to combat COVID-19 disease, published literature has described the role of kidney disease in COVID-19 patients based on single/multicenter experiences across the globe. We extracted data from observational studies describing comorbid CKD, AKI and CRRT and outcomes and severity of COVID-19-hospitalized patients from December 1, 2019–August 20, 2020 following PRISMA guidelines. Severity of COVID-19 includes intensive care unit admission, oxygen saturation < 90%, invasive mechanical ventilation utilization, in-hospital admission and mortality. Meta-analysis was performed using a random-effects model to calculate pooled estimates, and forest plots were created. In total, 29 studies with 15,017 confirmed COVID-19 patients were included. The overall prevalence of AKI was 11.6% [(430/3693)], comorbid CKD 9.7% [(1342/13,728)] and CRRT 2.58% [(102/3946)] in our meta-analysis. We also found higher odds of comorbid CKD (pooled OR: 1.70; 95%CI: 1.21–2.40; p = 0.002), AKI (8.28; 4.42–15.52; p < 0.00001) and utilization of CRRT (16.90; 9.00–31.74; p < 0.00001) in patients with severe COVID-19 disease. Conclusion Our meta-analysis suggests that comorbid CKD, AKI and utilization of CRRT were significantly associated with COVID-19 disease severity. Clinicians should focus on early triaging of COVID-19 patients with comorbid CKD and at risk for AKI to prevent complication and mortality. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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