| Autor: |
Clarke, Sophie A., Phylactou, Maria, Patel, Bijal, Mills, Edouard G., Muzi, Beatrice, Izzi‐Engbeaya, Chioma, Khoo, Bernard, Meeran, Karim, Comninos, Alexander N., Abbara, Ali, Tan, Tricia, Oliver, Nick, Dhillo, Waljit S. |
| Předmět: |
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| Zdroj: |
Diabetes, Obesity & Metabolism; Mar2022, Vol. 24 Issue 3, p570-574, 5p |
| Abstrakt: |
** denotes P <= 0.01 gl C-peptide levels and pre-existing diabetes C-peptide values at follow-up at least 3 months after initial presentation with COVID-19 compared with those without (median [IQR] C-peptide [pmol/L]: pre-existing diabetes 1550 [1285, 2638], no diabetes 1239 [675, 1622], I P i = .008) (Figure 1B). C-peptide and COVID-19 disease severity and management C-peptide levels were higher in those who had severe or critical disease compared with those with mild disease (median [IQR] C-peptide mild: 762 [510, 1289] pmol/L, severe/critical: 1538 [1143, 2906] pmol/L, I P i = .004) (Figure 1C). Hyperglycaemia1 and new diagnoses of diabetes (including autoantibody-negative type 1 diabetes2) have been reported in patients with coronavirus disease 2019 (COVID-19).1 Moreover, 77% of patients with COVID-19 and ketoacidosis (a condition typically associated with type 1 diabetes or pancreatic destruction) had type 2 diabetes.3 The receptor necessary for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry, ACE2, and its permissive protein, TMPRSS2, are present in the pancreatic microvasculature4 and, at postmortem, SARS-CoV-2 viral RNA has been detected in pancreatic beta cells.5 In islets infected with SARS-CoV-2, in vitro insulin secretion, particularly glucose-stimulated insulin secretion, is attenuated.6 Given this, it has been speculated that insulin secretory capacity may be curtailed by direct cytopathic action of SARS-CoV-2 on beta cells. C-peptide is preserved at follow-up at >=3 months following presentation with COVID-19 At the study visit appointment, which took place at least 3 months after initial presentation with COVID-19, median (IQR) C-peptide was 1319 (849, 1905) pmol/L and no patients had undetectable C-peptide levels (<3.3 pmol/L). [Extracted from the article] |
| Databáze: |
Complementary Index |
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