| Autor: |
Michel, Anna, Dinger, Thiemo, Darkwah Oppong, Marvin, Rauschenbach, Laurèl, Deuschl, Cornelius, Ahmadipour, Yahya, Pierscianek, Daniela, Wrede, Karsten, Hense, Jörg, Pöttgen, Christoph, Iannaccone, Antonella, Kimmig, Rainer, Sure, Ulrich, Jabbarli, Ramazan |
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| Zdroj: |
Acta Neurochirurgica; Feb2022, Vol. 164 Issue 2, p439-449, 11p |
| Abstrakt: |
Objective: Occurrence of brain metastases BM is associated with poor prognosis in patients with breast cancer (BC). Magnetic resonance imaging (MRI) is the standard of care in the diagnosis of BM and determines further treatment strategy. The aim of the present study was to evaluate the association between the radiographic markers of BCBM on MRI with other patients' characteristics and overall survival (OS). Methods: We included 88 female patients who underwent BCBM surgery in our institution from 2008 to 2019. Data on demographic, clinical, and histopathological characteristics of the patients and postoperative survival were collected from the electronic health records. Radiographic features of BM were assessed upon the preoperative MRI. Univariable and multivariable analyses were performed. Results: The median OS was 17 months. Of all evaluated radiographic markers of BCBM, only the presence of necrosis was independently associated with OS (14.5 vs 22.5 months, p = 0.027). In turn, intra-tumoral necrosis was more often in individuals with shorter time interval between BC and BM diagnosis (< 3 years, p = 0.035) and preoperative leukocytosis (p = 0.022). Moreover, dural affection of BM was more common in individuals with positive human epidermal growth factor receptor 2 status (p = 0.015) and supratentorial BM location (p = 0.024). Conclusion: Intra-tumoral necrosis demonstrated significant association with OS after BM surgery in patients with BC. The radiographic pattern of BM on the preoperative MRI depends on certain tumor and clinical characteristics of patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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