| Autor: |
Ikarashi, Daiki, Kitano, Shigehisa, Tsuyukubo, Takashi, Takenouchi, Kazumasa, Nakayama, Takayuki, Onagi, Hiroko, Sakaguchi, Asumi, Yamashita, Makiko, Mizugaki, Hidenori, Maekawa, Shigekatsu, Kato, Renpei, Kato, Yoichiro, Sugai, Tamotsu, Nakatsura, Tetsuya, Obara, Wataru |
| Předmět: |
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| Zdroj: |
British Journal of Cancer; Mar2022, Vol. 126 Issue 4, p606-614, 9p |
| Abstrakt: |
Background: We examined the relationship between the tumour microenvironment and the clinical efficacy of neoadjuvant chemotherapy in patients with cT2-4aN0M0 bladder cancer using multiplex fluorescence immunohistochemistry.Methods: The study retrospectively evaluated 51 patients who underwent radical cystectomy following neoadjuvant chemotherapy for cT2-4aN0M0 muscle-invasive bladder cancer. Patients were divided into responders (Results: The median age was 69 years; 39 patients were male. Twelve (23.5%), 17 (33.3%), 10 (19.7%) and 12 (23.5%) patients were pT0, pT1, pT2 and ≥pT3, respectively. Responders had a significantly higher 5-year cancer-specific survival rate (96.6%) than non-responders (48.4%; p = 0.0018). CD8+ T cell (p = 0.0056) and CD204+ cell (p = 0.0394) densities were significantly higher in the intratumoural area in non-responders than in responders. Patients with higher CD204+ cell densities in cancerous areas had worse prognosis.Conclusions: This comprehensive analysis of the immune microenvironment of a muscle-invasive bladder cancer specimen revealed that preexisting tumour-infiltrating proliferating CD8+ T cells and CD204+ cells are indicators of the response to neoadjuvant chemotherapy and that CD204+ cells can be considered an unfavourable prognostic factor in these patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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